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Invitrogen
CD200 Monoclonal Antibody (325516), PE
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CD200 Antibody (MA5-23576) in Flow
Flow cytometry of CD200 in Th17 differentiated human peripheral blood mononuclear cells (PBMCs). Samples were incubated in CD200 monoclonal antibody (Product # MA5-23576) followed by Mouse Anti-Human CD3ε APC‚conjugated Monoclonal Antibody. Quadrant markers were set based on control antibody staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-23576
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
325516
Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD200 Gln31-Gly232
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with ≤ 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant mouse CD200 is observed.
Target Information
CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody MRC OX-2; CD200 antigen; unnamed protein product
Gene Aliases: MOX1; MOX2; MRC; OX-2
UniProt ID: (Human) P41217
Entrez Gene ID: (Human) 4345
negative regulation of leukocyte activation
negative regulation of cell proliferation
negative regulation of interleukin-6 production
heterotypic cell-cell adhesion
regulation of macrophage activation
negative regulation of macrophage activation
positive regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
regulation of immune response
cellular response to lipopolysaccharide
cellular response to interferon-gamma
positive regulation of transforming growth factor beta production
cell-cell adhesion
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
negative regulation of matrix metallopeptidase secretion
negative regulation of macrophage migration
negative regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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