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Invitrogen
IFNAR2 Recombinant Rabbit Monoclonal Antibody (122)
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FIGURE: 1 / 1
IFNAR2 Antibody (MA5-35990) in Flow
Flow Cytometry analysis of IFNAR2 in Jurkat cells. Cells were stained with IFNAR2 Recombinant Monoclonal Antibody (Product # MA5-35990), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-35990
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
122
Immunogen
Recombinant Human IFNAR2 Protein (1-243).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-gamma) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha subtypes. IFN-alpha/betaR is expressed as two alternatively spliced transcripts, designated IFN-alpha/betaRalpha (IFN-alpha/betaR1) and IFN-alpha/betaRbeta (IFN-alpha/betaR2), both of which are involved in signal transduction and ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human interferon alpha/beta receptor; IFN alpha/betaRbeta; IFN R2; IFN-alpha/beta receptor 2; IFN-alpha/betaR2; IFN-alpha/betaRbeta; IFN-R-2; IFNalpha/beta R2; IFNalpha/beta receptor subunit 2; IFNalpha/beta-Rbeta; IFNalpha/betaR2; IFNAR2; IFNR2; interferon (alpha, beta and omega) receptor 2; Interferon alpha binding protein; Interferon alpha/beta receptor 2; interferon receptor; interferon-alpha/beta receptor beta chain; Type I interferon receptor 2; unnamed protein product
Gene Aliases: IFN-alpha-REC; IFN-R; IFN-R-2; IFNABR; IFNAR2; IFNARB; IMD45
UniProt ID: (Human) P48551
Entrez Gene ID: (Human) 3455
regulation of transcription from RNA polymerase II promoter
cell surface receptor signaling pathway
JAK-STAT cascade
response to virus
response to interferon-alpha
response to interferon-beta
cellular response to interferon-beta
regulation of JAK-STAT cascade
defense response to virus
type I interferon signaling pathway
cellular response to virus
positive regulation of protein localization to nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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