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Invitrogen
SIGIRR Recombinant Rabbit Monoclonal Antibody (010)
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FIGURE: 1 / 1
SIGIRR Antibody (MA5-36024) in Flow
Flow Cytometry analysis of SIGIRR in SW480 cells. Cells were stained with SIGIRR Recombinant Monoclonal Antibody (Product # MA5-36024), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Product Details
MA5-36024
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
010
Immunogen
Recombinant Human SIGIRR/TIR8 Protein (1-118).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC110992; SIGIRR; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR8; TIR8/SIGIRR; IL-1R8 Long 1; Toll/interleukin-1 receptor 8; unnamed protein product
Gene Aliases: IL-1R8; SIGIRR; TIR8; UNQ301/PRO342
UniProt ID: (Human) Q6IA17
Entrez Gene ID: (Human) 59307
negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
cell surface receptor signaling pathway
negative regulation of signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of chemokine production
negative regulation of Toll signaling pathway
negative regulation of interleukin-1-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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