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Invitrogen

Phospho-MEK3/MEK6 (Ser189, Ser207) Recombinant Rabbit Monoclonal Antibody (MKK3S189MKK6S207-D3)

View all (14) MEK3/MEK6 antibodies

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Phospho-MEK3/MEK6 (Ser189, Ser207) Recombinant Rabbit Monoclonal Antibody (MKK3S189MKK6S207-D3)

Product Details

MA5-37054

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Flow Cytometry (Flow)

1-1,000 ng/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MKK3S189MKK6S207-D3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser189 of human phospho MKK3 and Ser207 of human phospho MKK6.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

10 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896989

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Colorectal Cancer Metastasis-Suppressed LncRNA; Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 3; MAP kinase kinase 6; MAP2K3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; OTTHUMP00000166044; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK3; Stress-activated protein kinase kinase 2; Stress-activated protein kinase kinase 3; unnamed protein product

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Gene Aliases: AW212142; CRCMSL; MAP2K3; MAP2K6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK6; mMKK3b; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3; SKK2; SKK3

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UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236

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Entrez Gene ID: (Human) 5606, (Human) 5608, (Mouse) 26397, (Mouse) 26399

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding protein serine kinase activity identical protein binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade regulation of cytokine production response to ischemia inflammatory response signal transduction heart development stress-activated protein kinase signaling cascade negative regulation of hippo signaling cellular response to vascular endothelial growth factor stimulus p38MAPK cascade positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration positive regulation of protein kinase activity positive regulation of transcription, DNA-templated protein maturation cardiac muscle contraction pyroptosis cellular response to lipopolysaccharide cellular response to UV-B cellular response to sorbitol cellular senescence regulation of intracellular signal transduction NLRP1 inflammasome complex assembly osteoblast differentiation apoptotic process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway signal transduction in response to DNA damage stress-activated MAPK cascade regulation of cell cycle bone development negative regulation of cold-induced thermogenesis regulation of signal transduction by p53 class mediator activation of MAPK activity protein phosphorylation regulation of mitotic cell cycle phosphorylation regulation of cytokine biosynthetic process regulation of apoptotic process positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated regulation of signal transduction positive regulation of prostaglandin secretion positive regulation of apoptotic process positive regulation of nitric-oxide synthase biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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