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Invitrogen

Phospho-MEK1/MEK2 (Ser217, Ser221) Recombinant Rabbit Monoclonal Antibody (MEK12S217S221-H2)

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Phospho-MEK1/MEK2 (Ser217, Ser221) Recombinant Rabbit Monoclonal Antibody (MEK12S217S221-H2)

Product Details

MA5-37096

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Flow Cytometry (Flow)

1-1,000 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MEK12S217S221-H2

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Ser217/221 of human phospho MEK1/2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

10 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897030

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MEK 1; MEK 2; MEK-1; MEK-2; mitogen-activated protein kinase kinase 2, p45; MP2K1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

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Gene Aliases: CFC3; CFC4; MAP2K1; MAP2K2; MAPKK1; MAPKK2; MEK1; MEK2; MEL; MKK1; MKK2; PRKMK1; PRKMK2

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UniProt ID: (Human) Q02750, (Human) P36507

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Entrez Gene ID: (Human) 5604, (Human) 5605

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding kinase activity transferase activity protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity PDZ domain binding metal ion binding binding, bridging
Process(es)
MAPK cascade heart development positive regulation of gene expression Schwann cell development thyroid gland development regulation of stress-activated MAPK cascade peptidyl-serine autophosphorylation ERBB2-ERBB3 signaling pathway myelination positive regulation of transcription, DNA-templated insulin-like growth factor receptor signaling pathway thymus development regulation of axon regeneration positive regulation of axonogenesis face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance positive regulation of cell motility regulation of early endosome to late endosome transport regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction negative regulation of cell proliferation positive regulation of autophagy negative regulation of gene expression cerebellar cortex formation central nervous system neuron differentiation neuron differentiation keratinocyte differentiation positive regulation of cell migration melanosome transport positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion endodermal cell differentiation positive regulation of MAPK cascade type B pancreatic cell proliferation positive regulation of muscle contraction positive regulation of Ras protein signal transduction vesicle transport along microtubule Golgi inheritance response to axon injury neuron projection morphogenesis cell motility response to glucocorticoid Bergmann glial cell differentiation placenta blood vessel development labyrinthine layer development triglyceride homeostasis regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of endodermal cell differentiation negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway positive regulation of ATP biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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