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Invitrogen
HSP70 Monoclonal Antibody (7FB), APC
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Product Details
MA5-45331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
7FB
Immunogen
Prepared from Drosophila tissue culture cells heat shocked at 36.5C for 3 hours, and isolated using SDS PAGE.
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
1 µg/mL of MA5-45331 was sufficient for detection of Drosophila HSP70 using an indirect assay with rabbit anti-rat IgG and goat anti-rabbit IgG:HRP.|Detects approximately 70kDa (heat-inducible form).
Target Information
HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kilodalton heat shock protein; 87A locus; 87C locus; CG31359-PA; CG31366-PA; heat shock 70; Heat shock 70 kDa protein Aa; Heat shock 70 kDa protein Ab; Heat shock protein; heat shock protein 70; Heat shock protein 70 Aa; Heat shock protein 70 Ab; Heat shock protein 70Bb; Heat shock protein 70Bc; heat shock protein-70; heat-shock protein 70; HEL S 103; HSP; HSP70 1; HSP70 1B; HSP70 2; hsp70 87A; HSP70 AceyltK77; HSP70-87A7; HSP70-87C1; Hsp70Aa-PA; Hsp70Bb-PA; HSPA2; HSPA4; Hspa70; LP05203p; LP05233p; LP08776p; Major heat shock 70 kDa protein Bb; Major heat shock 70 kDa protein Bc; protein 70
Gene Aliases: 87A; Bb; CG18743; CG31359; CG31366; CG6489; dHSP70; dhsp70Aa; Dm-hsp70; Dmel\CG31359; Dmel\CG31366; Dmel_CG31359; Dmel_CG31366; DmHSP70AA; DMHSP7D1; hs70; HSP 70; Hsp-70; Hsp-70Aa; HSP70; hsp70 87A; hsp70 87C; hsp70 Aa; hsp70(87A); Hsp70(87C); Hsp70A; Hsp70A7d; Hsp70Aa; Hsp70Ab; Hsp70B; Hsp70Bb; Hsp70Bbc; Hsp70Bc
UniProt ID: (Fruit fly) P02825, (Fruit fly) Q9BIR7
Entrez Gene ID: (Fruit fly) 48581, (Fruit fly) 48582
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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