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Invitrogen
RBM8A Monoclonal Antibody (4C4), HRP
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Product Details
MA5-46553
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Xenopus
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4C4
Immunogen
Human full length native protein (purified)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Western blot detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).
Target Information
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: binder of ovarian cancer 1 protein BOV-1; binder of OVCA1; Binder of OVCA1-1; BOV-1; BOV1; BOV1A; BOV1B; BOV1C; exon junction complex core component Y14; RBM8A; ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; Ribonucleoprotein RBM8A-A; RNA binding motif protein 8B; rna-binding; RNA-binding motif protein 8A; RNA-binding motif protein 8A-A; RNA-binding protein 8A; RNA-binding protein 8A-A; RNA-binding protein Y14; unnamed protein product
Gene Aliases: BOV-1A; BOV-1B; BOV-1C; C1DELq21.1; DEL1q21.1; HSPC114; MDS014; RBM8; rbm8-A; RBM8A; rbm8a-A; rbm8a-b; RBM8B; TAR; tsunagi; XELAEV_18042903mg; Y14; ZNRP; ZRNP1
UniProt ID: (Human) Q9Y5S9, (Xenopus) Q9DF42
Entrez Gene ID: (Human) 9939, (Xenopus) 399167
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
RNA processing
mRNA processing
mRNA export from nucleus
regulation of translation
RNA splicing
regulation of mRNA processing
mRNA transport
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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