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Proteintech
MAEL Polyclonal Antibody
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Product Details
26666-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MAEL Fusion Protein Ag24524
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cancer/testis antigen 128; maelstrom homolog; Protein maelstrom homolog; RP11-102C16.1; spermatogenesis associated 35; testicular tissue protein Li 116; unnamed protein product
Gene Aliases: 4933405K18Rik; AU019877; CT128; MAEL; RGD1309333; SPATA35
UniProt ID: (Human) Q96JY0, (Mouse) Q8BVN9
Entrez Gene ID: (Human) 84944, (Rat) 364039, (Mouse) 98558
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
cellular response to DNA damage stimulus
synapsis
male meiosis
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
fertilization
negative regulation of gene expression
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
negative regulation of apoptotic process
regulation of organ growth
apoptotic process
gene expression
cell differentiation
ectopic germ cell programmed cell death
negative regulation of transcription, DNA-templated
negative regulation of developmental process
meiotic cell cycle
regulation of gene silencing by miRNA
transposable element silencing by piRNA-mediated DNA methylation
negative regulation of reproductive process
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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