Immunogen sequence: SSTELLRQLA RGGTMVTYGG MAKQPVVASV SLLIFKDLKL RGFWLSQWKK DHSPDQFKEL ILTLCDLIRR GQLTAPACSQ VPLQDYQSAL EASMKPFISS KQILTM
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 87%.
The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
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Protein Aliases: 2-enoyl thioester reductase; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; MECR; mitochondrial 2-enoyl thioester reductase; NBRF1; NRBF-1; nuclear receptor binding factor 1; Nuclear receptor-binding factor 1; Trans-2-enoyl-CoA reductase, mitochondrial
Gene Aliases: AI195831; CGI-63; FASN2B; MECR; NBRF1; NRBF1