FIGURE: 1 / 3
Immunogen sequence: QQLDRVDET PGPPHPKGPP RCSFSPRNSR HEGSFARQQS LYAPKGSVPS PSPRPQALDA TQVPSPLPLA QPSTPPVRRL ELLPSAESPV CWLEQPESHQ RLAGPGCKAG LSPAEPLLSL AGFSPDSSKA DSDAASSGGS DSKKKKRYRP RDYTVNLDGQ VAEAGVKPVR LKERKLTFDP MTRQIKPLTQ KEPVRADSPV HMEQQSRTEL DKQEAKASLQ SPFEQTNWKE LSRNEIIQSY LSRQSSLLSS SGAQTPGAHH FMSEYLKQEE STRQGARQLH VLVPQSPPTD LPGLTREVTQ DDLDRIQASQ WPGVNGCQDT QGNWYDWTQC ISLDPHGDDG RLNILPYVCL D (251-600 aa encoded by BC110430)
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
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Protein Aliases: Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; cofactor required for Sp1 transcriptional activation, subunit 7 (70kD); cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa; CRSP complex subunit 7; Mediator complex subunit 26; Mediator of RNA polymerase II transcription subunit 26; solute carrier family 35, member E1; Transcriptional coactivator CRSP70
Gene Aliases: 5730493L18Rik; AI414941; ARC70; AW495270; CRSP7; CRSP70; MED26; Slc35e1
Molecular Function: transcription cofactor