FIGURE: 1 / 2
Immunogen sequence: TQVSDFLSG RSPLTLALRV GDHMMFVQLQ LAAQHAPLQH RHVLAAAAAA AAARGDPSIA SPVSSPCRPV SSAARVPPVP TSPSPASPSP ITAGSFRSHA ASTTCPEQMD CSPTASSSAS PGASTTSTPG ASPAPRSRKP GAVIESFVNH APGVFSGTFS GTLHPNCQDS SGRPRRDIGT ILQILNDLLS ATRHYQGMPP SLAQLRCHAQ CSPASPAPDL APRTTSCEKL TAAPSASLLQ GQSQIRMCKP PGDRLRQTEN RATRCKVERL QLLLQQKRLR RKARRDARGP YHWSPSRKAG RSDSSSSGGG GSPSEASGLG LDFEDSVWKP EANPDIKSEF VVA (127-468 aa encoded by BC094778)
Expression of the midnolin gene is developmentally regulated: it is strongly expressed at the mesencephalon (midbrain) of the embryo in day 12.5 (E12.5) mice. The midnolin encodes a protein of 508 amino acids (aa), which contains a Ubiquitin-like domain. The intracellular distribution of the midnolin was studied by using midnolin-green fluorescent protein (GFP) fusion proteins. Midnolin was found to be localized in the nucleus and nucleolus, but not in the cytoplasm. The nucleolar localization signal was determined to be a 28aa peptide located at the C-terminal region of the midnolin. May be involved in regulation of genes related to neurogenesis in the nucleolus.
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Protein Aliases: DKFZp547M072; Midbrain nucleolar protein; Midnolin
Gene Aliases: 3000003C15Rik; MIDN