The antibody detects endogenous levels of total MRC2 protein.
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Protein Aliases: C-type lectin domain family 13 member E; C-type mannose receptor 2; CD280; collagen-binding factor Endo180; endocytic receptor (macrophage mannose receptor family); Endocytic receptor 180; Lectin lambda; Macrophage mannose receptor 2; mannose receptor, C type 2; novel lectin; UPAR-associated protein; Urokinase-type plasminogen activator receptor-associated protein
Gene Aliases: CD280; CLEC13E; ENDO180; KIAA0709; mKIAA0709; MRC2; UPARAP
Molecular Function: receptor