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Invitrogen
MRCK alpha Polyclonal Antibody
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FIGURE: 1 / 2
MRCK alpha Antibody (PA5-68391) in IHC (P)
Immunohistochemical analysis of MRCK alpha in paraffin-embedded Human liver cancer tissue using (left) MRCK alpha Polyclonal Antibody (Product # PA5-68391) at a 1:45 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-68391
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human MRCK alpha.
Conjugate
Form
Liquid
Concentration
1.6 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
CDC42BPA (MRCKA) is a serine/threonine kinase which functions in actin cytoskeleton assembly and organization. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 binding protein kinase alpha (DMPK-like); CDC42 binding protein kinase beta; CDC42-binding protein kinase alpha; cdc42bpa {ECO:0000250|UniProtKB:Q5VT25}; DKFZp686L1738; DKFZp686P1738; DMPK-like alpha; FLJ23347; MRCK alpha; MRCK-alpha; protein kinase; myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; RP5-1087E8.4; ser-thr protein kinase PK428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha; unnamed protein product
Gene Aliases: A930014J19Rik; CDC42BPA; DMPK-like; KIAA0451; MRCK; MRCKA; MRCKalpha; PK428
UniProt ID: (Human) Q5VT25, (Rat) O54874, (Mouse) Q3UU96
Entrez Gene ID: (Human) 8476, (Rat) 114116, (Mouse) 226751
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
identical protein binding
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
cytoskeleton organization
cell migration
actin cytoskeleton organization
actomyosin structure organization
microtubule cytoskeleton organization
nuclear migration
actin cytoskeleton reorganization
intracellular signal transduction
regulation of catalytic activity
regulation of small GTPase mediated signal transduction
phosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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