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Product Details
PA5-68391
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:30-1:150 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to residues near the C terminal of human MRCK alpha. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.6 mg/mL |
Purification |
affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 40% glycerol |
Contains |
0.05% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2692236 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
MRCK alpha (myotonic dystrophy kinase-related Cdc42-binding kinase alpha) is a member of the dystrophia myotonica protein kinase (DMPK) family that functions downstream of Cdc42 in actin cytoskeletal reorganization. It is a serine/threonine kinase with multiple functional domains, including phorbol ester-responsive C1 domain. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 binding protein kinase alpha (DMPK-like); CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha; CDC42-binding protein kinase alpha (DMPK-like); CDC42BPA; cdc42bpa {ECO:0000250|UniProtKB:Q5VT25}; DKFZp686L1738; DKFZp686P1738; DMPK-like alpha; FLJ23347; MRCK alpha; myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; RP5-1087E8.4; ser-thr protein kinase PK428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha
Gene Aliases: A930014J19Rik; CDC42BPA; DMPK-like; KIAA0451; MRCK; MRCKA; PK428
UniProt ID: (Human) Q99646, (Rat) O54874, (Mouse) Q3UU96
Entrez Gene ID: (Human) 8476, (Rat) 114116, (Mouse) 226751
Molecular Function:
non-receptor serine/threonine protein kinase
protein phosphorylation
cell migration
actomyosin structure organization
actin cytoskeleton reorganization
intracellular signal transduction
microtubule cytoskeleton organization
cytoskeleton organization
nuclear migration
regulation of catalytic activity
regulation of small GTPase mediated signal transduction
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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