Immunogen sequence: TAPLVVVVST TGTGDPPDTA RKFVKEIQNQ TLPVDFFAHL RYGLLGLGDS EYTYFCNGGK IIDKRLQELG ARHFYDTGHA DDCVGLELVV EPWIAGLWPA LRKHFRSSRG QEEISGALPV ASPASSRTDL VKSELLHIES QVELLRFDDS GRKDSEVLKQ NAVNSNQSNV VIEDFESSLT R; Positive Samples: A-549, HeLa, LO2, 293T; Cellular Location: Cytoplasm, Cytoplasm
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing); Methionine synthase reductase; methionine synthase reductase, mitochondrial; MSR
Gene Aliases: cblE; MSR; MTRR
UniProt ID: (Human) Q9UBK8
Entrez Gene ID: (Human) 4552