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Invitrogen
MYST1 Polyclonal Antibody
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FIGURE: 1 / 1
MYST1 Antibody (PA5-96098) in WB
Western blot analysis of MYST1 in extracts of various cell lines. Samples were incubated with MYST1 Polyclonal antibody (Product # PA5-96098) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96098
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KAT8/MYST1/MOF (NP_8920032)
Conjugate
Form
Liquid
Concentration
1.76 mg/mL
Amount
176 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE PEVTVEIGET YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD KIHIGNYEID AWYFSPFPED; Positive Samples: OVCAR3, NIH/3T3; Cellular Location: Chromosome, Nucleus
Target Information
The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3), yeast YBF2 and SAS2, and TIP60 (HTATIP). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h FLJ14040; Histone acetyltransferase KAT8; histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; Lysine acetyltransferase 8; Males-absent on the first protein homolog; mMof; MOF; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST family member; MYST histone acetyltransferase 1; MYST protein 1; MYST-1; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1; Protein acetyltransferase KAT8; Protein propionyltransferase KAT8; unnamed protein product
Gene Aliases: 2010203C02Rik; 5830450F21Rik; D7Ertd629e; hMOF; KAT8; LIGOWS; MOF; MYST1; PP7073; ZC2HC8
UniProt ID: (Human) Q9H7Z6, (Mouse) Q9D1P2, (Rat) Q5XI06
Entrez Gene ID: (Human) 84148, (Mouse) 67773, (Rat) 310194
transcription coactivator activity
histone acetyltransferase activity
protein binding
zinc ion binding
H4 histone acetyltransferase activity
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
enzyme binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
RNA polymerase II sequence-specific DNA binding transcription factor binding
peptide-lysine-N-acetyltransferase activity
protein propionyltransferase activity
DNA-binding transcription factor binding
promoter-specific chromatin binding
transcription factor binding
transferase activity, transferring acyl groups other than amino-acyl groups
methylated histone binding
molecular_function
histone modifying enzyme
epithelial to mesenchymal transition
chromatin organization
regulation of transcription, DNA-templated
dosage compensation by inactivation of X chromosome
regulation of autophagy
negative regulation of macromolecule biosynthetic process
positive regulation of epithelial to mesenchymal transition
negative regulation of epithelial to mesenchymal transition
skeletal muscle satellite cell differentiation
neurogenesis
hemopoiesis
myeloid cell differentiation
negative regulation of type I interferon production
positive regulation of type I interferon production
post-embryonic hemopoiesis
regulation of gene expression, epigenetic
regulation of cell differentiation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
oogenesis
regulation of mRNA processing
negative regulation of multicellular organismal process
positive regulation of transcription initiation from RNA polymerase II promoter
membraneless organelle assembly
positive regulation of skeletal muscle satellite cell differentiation
regulation of transcription from mitochondrial promoter
transcription, DNA-templated
chromatin modification
histone acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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