|Western Blot (WB)||0.3-1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (KDFPEEDDPTN) corresponding to the internal amino acids of NCF4|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine based on sequence homology.
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 to form a complex with neutrophil cytosolic factor 1 kinase, which suggests its role in PIkinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTA-833B7.1; MGC3810; NCF; NCF-4; NCF4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4 (40kD); neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; OTTHUMP00000028736; OTTHUMP00000043756; p40-phox; P40PHOX; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Aliases: CGD3; NCF; NCF4; P40PHOX; SH3PXD4
UniProt ID: (Human) Q15080
Entrez Gene ID: (Human) 4689
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