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Proteintech
NCOR1 Polyclonal Antibody
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Product Details
20018-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody recognizes the N-term of NCOR1.
Target Information
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: h KIAA1047; hCIT529I10; MGC104216; N-CoR; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13; N-CoR1; NCoR; nrcr; nuclear receptor corepressor; Nuclear receptor corepressor 1; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; thyroid hormone- and retinoic acid receptor-associated corepressor 1; unnamed protein product
Gene Aliases: 5730405M06Rik; A230020K14Rik; hN-CoR; KIAA1047; mKIAA1047; N-CoR; N-CoR1; NCOR1; PPP1R109; RIP13; Rxrip13; TRAC1
UniProt ID: (Human) O75376
Entrez Gene ID: (Human) 9611, (Rat) 54299, (Mouse) 20185
transcription regulatory region sequence-specific DNA binding
DNA binding
transcription corepressor activity
protein binding
ligand-dependent nuclear receptor binding
histone deacetylase binding
thyroid hormone receptor binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II regulatory region DNA binding
RNA polymerase II activating transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein domain specific binding
estrogen receptor binding
histone deacetylase regulator activity
nuclear hormone receptor binding
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoid X receptor binding
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of cellular ketone metabolic process
locomotor rhythm
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
negative regulation of fatty acid metabolic process
negative regulation of JNK cascade
rhythmic process
spindle assembly
negative regulation of androgen receptor signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
skeletal muscle tissue development
lactation
positive regulation of cell proliferation
negative regulation of gene expression
negative regulation of phosphatidylinositol 3-kinase signaling
chromatin modification
cerebellum development
thalamus development
regulation of histone deacetylation
positive regulation of histone deacetylation
circadian regulation of gene expression
regulation of multicellular organism growth
cholesterol homeostasis
regulation of catalytic activity
definitive erythrocyte differentiation
regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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