NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
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Protein Aliases: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR alpha; LXRb; NER; NERI; NR1H2; nuclear orphan receptor LXR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD-1; ubiquitously-expressed nuclear receptor 1
Gene Aliases: AU018371; LXR; LXR-a; LXRA; LXRalpha; NR1H3; RLD-1; RLD1; Unr1