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Proteintech
NR5A2 Polyclonal Antibody
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Product Details
22460-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NR5A2 Fusion Protein Ag18001 (143-332 aa encoded by BC118652)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NGLKLEAMS QVIQAMPSDL TISSAIQNIH SASKGLPLNH AALPPTDYDR SPFVTSPISM TMPPHGSLQG YQTYGHFPSR AIKSEYPDPY TSSPESIMGY SYMDSYQTSS PASIPHLILE LLKCEPDEPQ VQAKIMAYLQ QEQANRSKHE KLSTFGLMCK MADQTLFSIV EWARSSIFFR ELKVDDQMKL L (143-332 aa encoded by BC118652)
Target Information
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; Fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTF; similar to nuclear hormone receptor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; Liver receptor homolog 1; LRH-1; mFTF; Nuclear receptor subfamily 5 group A member 2; nuclear receptor; similar to FTZ-F1; orphan nuclear receptor; unnamed protein product
Gene Aliases: AU020803; B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2; UF2-H3B
UniProt ID: (Human) O00482, (Rat) Q9QWM1, (Mouse) P45448
Entrez Gene ID: (Human) 2494, (Rat) 60349, (Mouse) 26424
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
lipid binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
steroid hormone receptor activity
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
primary ovarian follicle growth
inner cell mass cell differentiation
positive regulation of T cell anergy
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
bile acid metabolic process
hormone-mediated signaling pathway
embryo development ending in birth or egg hatching
tissue development
neurogenesis
intracellular receptor signaling pathway
exocrine pancreas development
positive regulation of glucocorticoid biosynthetic process
negative regulation of chondrocyte differentiation
somatic stem cell population maintenance
embryonic cleavage
positive regulation of T cell proliferation
regulation of cell proliferation
homeostatic process
cholesterol homeostasis
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of inflammatory response
positive regulation of T cell activation
cartilage development
Sertoli cell development
pancreas morphogenesis
acinar cell differentiation
calcineurin-mediated signaling
morula formation
zygotic genome activation
cellular response to leukemia inhibitory factor
positive regulation of stem cell differentiation
positive regulation of tendon cell differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
epithelial cell differentiation
steroid hormone mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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