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Proteintech
NRAMP1 Polyclonal Antibody
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Product Details
32308-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
400 µg/mL
Amount
60 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leishmaniasis resistance; Natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; Solute carrier family 11 member 1; unnamed protein product
Gene Aliases: LSH; NRAMP; NRAMP1; SLC11A1
UniProt ID: (Human) P49279
Entrez Gene ID: (Human) 6556
negative regulation of cytokine production
positive regulation of cytokine production
T cell proliferation involved in immune response
positive regulation of dendritic cell antigen processing and presentation
positive regulation of T-helper 1 type immune response
ion transport
iron ion transport
manganese ion transport
cellular iron ion homeostasis
phagocytosis
inflammatory response
vacuolar acidification
response to bacterium
positive regulation of gene expression
nitrite transport
antimicrobial humoral response
metal ion transport
cellular manganese ion homeostasis
response to lipopolysaccharide
positive regulation of interferon-gamma production
response to interferon-gamma
iron ion transmembrane transport
wound healing
macrophage activation
defense response to bacterium
defense response to protozoan
MHC class II biosynthetic process
cell redox homeostasis
respiratory burst
positive regulation of transcription from RNA polymerase II promoter
antigen processing and presentation of peptide antigen
mRNA stabilization
positive regulation of phagocytosis
defense response to Gram-negative bacterium
establishment of localization in cell
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
manganese ion transmembrane transport
cellular detoxification of cadmium ion
hydrogen ion transmembrane transport
arginine transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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