This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: TWDLGNGAAW HWDLLAQEAA SCYDHPCFLR GMGDPVQSWK GPGLPRAGCS GLGHPIQLDP NQKTPENSKS LNAVYPRAGS KPPSCP
Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 27%.
OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (2-5')oligo(A) synthase 3; (2-5')oligo(A) synthetase 3; 2'-5'-oligoadenylate synthase 3; 2'-5'-oligoadenylate synthetase 3, 100kDa; 2'-5'oligoadenylate synthetase p100; 2-5A synthase 3; 2-5A synthetase 3; p100 OAS; p100OAS
Gene Aliases: OAS3; P/OKcl.4; p100; p100OAS
UniProt ID: (Human) Q9Y6K5
Entrez Gene ID: (Human) 4940
Molecular Function: nucleotidyltransferase