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Alomone Labs, LTD

P2X4 Receptor Polyclonal Antibody

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P2X4 Receptor Polyclonal Antibody

Product Details

APR-002-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KKYKYVEDYEQGLSGEMNQ, corresponding to amino acid residues 370-388 of rat P2X4 receptor, Intracellular, C-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP receptor; ATP-gated cation channel protein; ionotropic ATP receptor subtype; ionotropic purinergic receptor; ligand gated ion channel; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4; unnamed protein product

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Gene Aliases: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R

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UniProt ID: (Human) Q99571, (Rat) P51577

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Entrez Gene ID: (Human) 5025, (Mouse) 18438, (Rat) 29659

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Function(s)
nucleotide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding ion channel activity copper ion binding protein binding ATP binding zinc ion binding identical protein binding cadherin binding ligand-gated calcium channel activity drug binding ligand-gated ion channel
Process(es)
tissue homeostasis regulation of sodium ion transport response to ischemia ion transport response to stress signal transduction regulation of blood pressure positive regulation of calcium ion transport into cytosol negative regulation of cardiac muscle hypertrophy regulation of metal ion transport sensory perception of pain calcium-mediated signaling positive regulation of cell migration positive regulation of prostaglandin secretion response to ATP ion transmembrane transport response to fluid shear stress purinergic nucleotide receptor signaling pathway endothelial cell activation positive regulation of blood vessel endothelial cell migration positive regulation of nitric oxide biosynthetic process behavioral response to pain response to axon injury positive regulation of calcium-mediated signaling regulation of chemotaxis sensory perception of touch positive regulation of protein kinase B signaling membrane depolarization positive regulation of calcium ion transport regulation of cardiac muscle contraction relaxation of cardiac muscle excitatory postsynaptic potential calcium ion transmembrane transport cellular response to zinc ion cellular response to ATP apoptotic signaling pathway cation transmembrane transport regulation of ruffle assembly positive regulation of intracellular signal transduction positive regulation of microglial cell migration positive regulation of endothelial cell chemotaxis nitric oxide biosynthetic process transport calcium ion transport neuronal action potential vasodilation protein homooligomerization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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