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Invitrogen
APBB2 Polyclonal Antibody
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FIGURE: 1 / 5
APBB2 Antibody (PA5-101421) in IHC (P)
Immunohistochemistry analysis of APBB2 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with APBB2 polyclonal antibody (Product # PA5-101421) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101421
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human APBB2(Accession Q92870), corresponding to amino acid residues Q493-E543.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total APBB2.
Target Information
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta precursor protein and amyloid beta precursor-like protein 2. This protein contains two phosphotyrosine binding domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyloid beta (A4) precursor protein-binding family B member 2 isoform APBB2_1; amyloid beta (A4) precursor protein-binding family B member 2 isoform APBB2_2; amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta A4 precursor protein-binding family B member 2; Amyloid beta precursor protein binding family B member 2; Amyloid-beta (A4) precursor protein-binding family B member 2; Fe65-like 1; Protein Fe65-like 1; unnamed protein product; zinc finger-like protein
Gene Aliases: 2310007D03Rik; APBB2; FE65L; FE65L1; RGD1562438; Rirl1; TR2L; Zfra
UniProt ID: (Human) Q92870, (Mouse) Q9DBR4
Entrez Gene ID: (Human) 323, (Rat) 305338, (Mouse) 11787
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of transcription, DNA-templated
smooth muscle contraction
axon guidance
extracellular matrix organization
intracellular signal transduction
maintenance of lens transparency
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
synapse organization
negative regulation of cell cycle phase transition
cell cycle arrest
biological_process
negative regulation of cell growth
actin filament-based movement
protein stabilization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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