Search

  • Contact Us
  • Quick Order

Invitrogen

Phospho-CDK2 (Thr160) Polyclonal Antibody

View all (64) CDK2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-CDK2 (Thr160) Polyclonal Antibody

Product Details

PA5-104849

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDK2(Accession P24941), corresponding to amino acid residues around phosphorylated Thr160.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816322

Product Specific Information

Antibody detects endogenous levels of CDK2 only when phosphorylated at Threonine 160.

Target Information

CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; CDK2; Cell division protein kinase 2; cyclin dependent kinase 2-alpha; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product

View more View less

Gene Aliases: A630093N05Rik; CDK2; CDKN2; p33(CDK2)

View more View less

UniProt ID: (Human) P24941, (Mouse) P97377

View more View less

Entrez Gene ID: (Human) 1017, (Rat) 362817, (Mouse) 12566

View more View less

Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein domain specific binding cyclin binding histone kinase activity metal ion binding cyclin-dependent protein kinase activity protein serine kinase activity protein complex binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter telomere maintenance DNA replication DNA repair chromatin remodeling transcription, DNA-templated protein phosphorylation potassium ion transport cellular response to DNA damage stimulus centriole replication signal transduction Ras protein signal transduction regulation of mitotic cell cycle positive regulation of cell proliferation regulation of G2/M transition of mitotic cell cycle regulation of gene expression peptidyl-serine phosphorylation positive regulation of heterochromatin assembly mitotic G1 DNA damage checkpoint protection from non-homologous end joining at telomere positive regulation of DNA-dependent DNA replication initiation telomere maintenance in response to DNA damage post-translational protein modification positive regulation of DNA replication positive regulation of transcription, DNA-templated centrosome duplication cell division meiotic cell cycle cellular response to nitric oxide cellular senescence regulation of anaphase-promoting complex-dependent catabolic process lens development in camera-type eye mitotic nuclear division response to toxic substance histone phosphorylation organ regeneration response to estradiol cellular response to insulin stimulus response to drug response to ethanol response to cadmium ion response to cAMP response to electrical stimulus regulation of cell cycle regulation of gene silencing cell cycle phosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support