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Invitrogen
Calpain 10 Polyclonal Antibody
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FIGURE: 1 / 4
Calpain 10 Antibody (PA5-106623) in ICC/IF
Immunocytochemistry analysis of Calpain 10 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Calpain 10 polyclonal antibody (Product # PA5-106623) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated... View More
Product Details
PA5-106623
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CAPN10(Accession Q9HC96), corresponding to amino acid residues L34-K84.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CAPN10.
Target Information
The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-activated neutral proteinase 10; calpain 8; Calpain-10; calpain-like protease CAPN10; CANP 10; unnamed protein product
Gene Aliases: AW049679; CANP10; CAPN10; Capn8; KIAA1845; mKIAA1845; NIDDM1
UniProt ID: (Human) Q9HC96, (Mouse) Q9ESK3
Entrez Gene ID: (Human) 11132, (Mouse) 23830
proteolysis
cellular component disassembly involved in execution phase of apoptosis
positive regulation of insulin secretion
positive regulation of intracellular transport
cellular response to insulin stimulus
regulation of actin cytoskeleton organization
positive regulation of glucose import
type B pancreatic cell apoptotic process
vesicle-mediated transport to the plasma membrane
positive regulation of type B pancreatic cell apoptotic process
mitophagy
mitochondrion organization
aging
actin cytoskeleton reorganization
response to nutrient levels
positive regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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