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Invitrogen

LIS1 Polyclonal Antibody

View all (13) LIS1 antibodies

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LIS1 Polyclonal Antibody

Product Details

PA5-115515

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PAFAH1B1(Accession P43034), corresponding to amino acid residues A378-R410.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900151

Product Specific Information

Antibody detects endogenous levels of total LIS1.

Target Information

VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: LIS-1; LIS-1 {ECO:0000255|HAMAP-Rule:MF_03141}; lissencephaly 1 protein; Lissencephaly-1 protein; lissencephaly-1 protein {ECO:0000255|HAMAP-Rule:MF_03141}; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF acetylhydrolase 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH 45 kDa subunit; PAF-AH 45 kDa subunit {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH alpha; PAF-AH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PAF-AH beta; PAFAH alpha; PAFAH alpha {ECO:0000255|HAMAP-Rule:MF_03141}; PHFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta); Platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}; Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa; RP23-194P5.2; unnamed protein product

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Gene Aliases: LIS-1; LIS1; LIS2; MDCR; MDS; Mdsh; MMS10-U; Ms10u; NudF; PAFAH; PAFAH1B1; PAFAHA

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UniProt ID: (Human) P43034, (Rat) P63004, (Mouse) P63005

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Entrez Gene ID: (Human) 5048, (Rat) 83572, (Mouse) 18472

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Function(s)
protein binding microtubule binding heparin binding dynactin binding identical protein binding phospholipase binding macromolecular complex binding dynein intermediate chain binding protein heterodimerization activity microtubule plus-end binding phosphoprotein binding dynein complex binding protein complex binding protein homodimerization activity dynein binding platelet-activating factor acetyltransferase activity
Process(es)
establishment of mitotic spindle orientation microtubule cytoskeleton organization ameboidal-type cell migration acrosome assembly neuron migration positive regulation of cytokine-mediated signaling pathway microtubule-based process mitotic nuclear division nuclear migration chemical synaptic transmission neuroblast proliferation brain development learning or memory retrograde axonal transport adult locomotory behavior protein secretion negative regulation of neuron projection development lipid catabolic process cell migration stem cell division transmission of nerve impulse corpus callosum morphogenesis hippocampus development layer formation in cerebral cortex cerebral cortex neuron differentiation cerebral cortex development actin cytoskeleton organization microtubule organizing center organization osteoclast development positive regulation of axon extension positive regulation of mitotic cell cycle negative regulation of JNK cascade vesicle transport along microtubule brain morphogenesis neuromuscular process controlling balance nuclear envelope disassembly establishment of centrosome localization lipid metabolic process JNK cascade germ cell development nervous system development cell differentiation forebrain development reelin-mediated signaling pathway positive regulation of embryonic development establishment of planar polarity of embryonic epithelium cortical microtubule organization platelet activating factor metabolic process modulation of synaptic transmission microtubule sliding positive regulation of cellular component organization cell division establishment of localization in cell establishment of organelle localization maintenance of centrosome location auditory receptor cell development positive regulation of dendritic spine morphogenesis regulation of microtubule cytoskeleton organization cochlea development microtubule cytoskeleton organization involved in establishment of planar polarity myeloid leukocyte migration regulation of postsynapse organization radial glia-guided pyramidal neuron migration interneuron migration transport cell cycle multicellular organism development regulation of GTPase activity
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