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Invitrogen

CYP11B1/CYP11B2 Polyclonal Antibody

View all (3) CYP11B1/CYP11B2 antibodies

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CYP11B1/CYP11B2 Polyclonal Antibody

Product Details

PA5-143908

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/10x^6 cells
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human CYP11B1/C11B2/CYP11B2 recombinant protein (Position: M1-P491).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.01mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3075122

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: rat kidney tissue, mouse kidney tissue. Flow: 293T cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

The steroid 11beta-hydroxylase gene, also designated Cyp11b-1, is a marker for the functional differentiation of cells in the zonae fasciculata reticularis. The deduced protein CYP11B1 consists of 466 amino acids containing a secretory signal, epidermal growth factor-like repeats, and a proteolytically inactive cathepsin B-related sequence. A related protein, human aldosterone synthase (CYP11B2), is involved in substrate recognition and conversion, with a functionally significant residue 112 in the N-terminal region of human CYP11B2. The inherited disorder glucocorticoid-remediable aldosteronism is caused by a chimeric gene duplication between the CYP11B1 and CYP11B2 genes. This disorder is characterized by hyperaldosteronism and high levels of 18-hydroxycortisol and 18-oxocortisol, which are under ACTH control.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; Corticosterone 18-monooxygenase, CYP11B2; CYP11B1; CYP11B1-V316M; CYPXIB1; CYPXIB2; CYPXIB3; Cytochrome P-450Aldo; Cytochrome P-450c11; Cytochrome P-450C18; Cytochrome P450 11B1, mitochondrial; Cytochrome P450 11B2, mitochondrial; cytochrome P450 11B3, mitochondrial; Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase); cytochrome p450 XIB1; cytochrome P450(11 beta)-DS; cytochrome P450, family 11, subfamily B, polypeptide 1; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily 11B, polypeptide 1; cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase); Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; Cytochrome P450C11; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P450(11 beta)-DS; P450-Aldo-1; P450-Aldo-2; P450C11; steroid 11-beta-hydroxylase; Steroid 11-beta-hydroxylase, CYP11B1; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo; steroid-11-beta-hydroxylase; unnamed protein product

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Gene Aliases: AA389061; ALDOS; Cp11ba; Cp45as; CPN1; CPN2; CYP11B; Cyp11b-1; Cyp11b-2; CYP11B1; CYP11B2; Cyp11b3; CYP11BL; CYPXIB2; FHI; P-450C18; P450aldo; P450C11; P450C18; RATCP11BA; RNCP45AS; S11BH

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UniProt ID: (Human) P15538, (Human) P19099, (Mouse) P15539

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Entrez Gene ID: (Human) 1584, (Human) 1585, (Mouse) 110115, (Rat) 500892, (Mouse) 13072, (Rat) 24294

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Function(s)
monooxygenase activity steroid 11-beta-monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen heme binding metal ion binding corticosterone 18-monooxygenase activity steroid hydroxylase activity steroid binding
Process(es)
regulation of blood volume by renal aldosterone C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process aldosterone biosynthetic process potassium ion homeostasis sodium ion homeostasis oxidation-reduction process regulation of systemic arterial blood pressure by circulatory renin-angiotensin steroid biosynthetic process regulation of blood pressure cortisol biosynthetic process drinking behavior positive regulation of blood pressure ion homeostasis response to nutrient response to salt stress cellular response to nutrient response to insulin cellular response to hormone stimulus cellular response to potassium ion response to drug response to peptide hormone cellular response to potassium ion starvation cellular response to mechanical stimulus cellular response to peptide hormone stimulus alcohol metabolic process lipid metabolic process immune response cholesterol metabolic process sterol metabolic process cortisol metabolic process glucose homeostasis renal water homeostasis mineralocorticoid biosynthetic process steroid metabolic process glucocorticoid metabolic process dibenzo-p-dioxin metabolic process adenosine metabolic process cellular response to interferon-gamma response to dexamethasone
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