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Invitrogen
VEGF Receptor 2 Polyclonal Antibody
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Product Details
PA5-16487
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat,
Rhesus monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from C-terminus of the precursor form of the mouse Flk-1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA5-16487 targets Flk-1 in IHC (P) and WB applications and shows reactivity with mouse, Rat, and Human samples.
The PA5-16487 immunogen is a synthetic peptide from C-terminus of the precursor form of the mouse Flk-1.
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2; VEGFR-2; tyrosine kinase
Gene Aliases: 6130401C07; CD309; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2
UniProt ID: (Human) P35968, (Rat) O08775, (Mouse) P35918
Entrez Gene ID: (Human) 3791, (Rat) 25589, (Mouse) 16542
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
coreceptor activity
kinase activity
transferase activity
growth factor binding
vascular endothelial growth factor binding
identical protein binding
cadherin binding
Hsp90 protein binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
angiogenesis
ovarian follicle development
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
vasculature development
lymph vessel development
positive regulation of mesenchymal cell proliferation
epithelial cell maturation
endocardium development
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
mesenchymal cell proliferation
positive regulation of endothelial cell migration
negative regulation of gene expression
positive regulation of macroautophagy
cell migration
peptidyl-tyrosine phosphorylation
hemopoiesis
cell differentiation
lung development
positive regulation of cell migration
positive regulation of BMP signaling pathway
embryonic hemopoiesis
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-2 signaling pathway
vascular endothelial growth factor signaling pathway
negative regulation of apoptotic process
surfactant homeostasis
regulation of MAPK cascade
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
cell fate commitment
endothelial cell differentiation
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
lung alveolus development
post-embryonic camera-type eye morphogenesis
branching morphogenesis of an epithelial tube
epithelial cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
calcium ion homeostasis
epithelial tube morphogenesis
blood vessel endothelial cell differentiation
vascular wound healing
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
stem cell proliferation
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of mitochondrial fission
positive regulation of nitric oxide-cGMP mediated signal transduction
regulation of hematopoietic progenitor cell differentiation
regulation of bone development
cellular response to hydrogen sulfide
negative regulation of endothelial cell apoptotic process
positive regulation of stem cell proliferation
positive regulation of endothelial cell chemotaxis
positive regulation of vasculogenesis
response to hypoxia
cell migration involved in sprouting angiogenesis
endochondral bone growth
positive regulation of cytosolic calcium ion concentration
aging
male gonad development
positive regulation of phosphatidylinositol 3-kinase signaling
hyaluronan metabolic process
positive regulation of TOR signaling
calcium-mediated signaling using intracellular calcium source
peptidyl-tyrosine autophosphorylation
response to drug
regulation of endothelial cell differentiation
positive regulation of vasodilation
positive regulation of long-term neuronal synaptic plasticity
cell maturation
neuron projection morphogenesis
positive regulation of neurogenesis
positive regulation of calcium-mediated signaling
positive regulation of nitric-oxide synthase biosynthetic process
response to oxygen levels
regulation of endothelial cell proliferation
protein phosphorylation
multicellular organism development
phosphorylation
positive regulation of vascular endothelial growth factor receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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