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Invitrogen
CD98 Polyclonal Antibody
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FIGURE: 1 / 4
CD98 Antibody (PA5-21547) in ICC/IF
Immunofluorescence analysis of CD98 was performed using log phase Jurkat cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with CD98 Polyclonal Antibody (Product # PA5-21547) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a diluti... View More
Product Details
PA5-21547
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CD98. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
19 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Dog (83%), Rabbit (83%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4F2 antigen heavy chain; 4F2 cell-surface antigen; 4F2 cell-surface antigen heavy chain; 4F2 heavy chain antigen; 4F2hc; Amino acid transporter heavy chain SLC3A2; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; CD98; CD98 heavy chain; lymphocyte activation antigen; Lymphocyte activation antigen 4F2 large subunit; monoclonal antibody 44D7; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; solute carrier family 3 (amino acid transporter heavy chain), member 2; Solute carrier family 3 member 2; unnamed protein product
Gene Aliases: 4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1; NACAE; SLC3A2
UniProt ID: (Human) P08195
Entrez Gene ID: (Human) 6520
virus receptor activity
RNA binding
double-stranded RNA binding
protein binding
aromatic amino acid transmembrane transporter activity
neutral amino acid transmembrane transporter activity
L-alanine transmembrane transporter activity
L-leucine transmembrane transporter activity
protein homodimerization activity
cadherin binding
protein heterodimerization activity
exogenous protein binding
carbohydrate metabolic process
calcium ion transport
amino acid transport
isoleucine transport
leucine transport
methionine transport
phenylalanine transport
proline transport
tryptophan transport
tyrosine transport
valine transport
response to exogenous dsRNA
viral entry into host cell
thyroid hormone transport
L-histidine transport
L-leucine import across plasma membrane
L-alanine import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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