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Invitrogen
JMJD6 Polyclonal Antibody
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Product Details
PA5-22132
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PSR. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, NIH-3T3.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (87%), Xenopus laevis (87%), Chicken (96%), Chimpanzee (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic cell clearance receptor PtdSerR; arginine demethylase and lysine hydroxylase; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR; unnamed protein product
Gene Aliases: 5730436I23Rik; D11Ertd195e; JMJD6; KIAA0585; mKIAA0585; PSR; PtdSerR; PTDSR; PTDSR1
UniProt ID: (Human) Q6NYC1, (Mouse) Q9ERI5
Entrez Gene ID: (Human) 23210, (Mouse) 107817
RNA binding
single-stranded RNA binding
iron ion binding
protein binding
oxidoreductase activity
histone demethylase activity
histone demethylase activity (H3-R2 specific)
histone demethylase activity (H4-R3 specific)
oxidative RNA demethylase activity
signaling receptor activity
identical protein binding
metal ion binding
dioxygenase activity
peptidyl-lysine 5-dioxygenase activity
P-TEFb complex binding
protein demethylase activity
transcription regulator activator activity
sulfonate dioxygenase activity
receptor activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
protein modifying enzyme
blood vessel development
kidney development
sprouting angiogenesis
chromatin organization
chromatin remodeling
mRNA processing
phagocytosis
cell surface receptor signaling pathway
heart development
RNA splicing
peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
cell differentiation
lung development
negative regulation of protein homooligomerization
T cell differentiation in thymus
oxidative RNA demethylation
macrophage activation
apoptotic cell clearance
recognition of apoptotic cell
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of mRNA splicing, via spliceosome
erythrocyte development
protein homooligomerization
retina development in camera-type eye
membraneless organelle assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
chromatin modification
oxidation-reduction process
histone H3-R2 demethylation
histone H4-R3 demethylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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