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Invitrogen
TRPV4 Polyclonal Antibody
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Product Details
PA5-41066
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human TRPV4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: RVDEVNWSHW NQNLGIINED PGKNETYQYY GFSHTVGRLR RDRWSSVVPR
Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 100%; Rat: 93%
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ion channel; ion channel protein; Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; Transient receptor potential protein 12; TRP12; TRPV4; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; vanilloid receptor-related osmotically activated channel (Vroac); Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2
Gene Aliases: BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; TRPV4; VRL2; VROAC
UniProt ID: (Human) Q9HBA0, (Rat) Q9ERZ8
Entrez Gene ID: (Human) 59341, (Rat) 66026
nucleotide binding
actin binding
osmosensor activity
protein kinase C binding
ion channel activity
cation channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
microtubule binding
lipid binding
stretch-activated, cation-selective, calcium channel activity
protein kinase binding
SH2 domain binding
identical protein binding
alpha-tubulin binding
metal ion binding
beta-tubulin binding
actin filament binding
ion channel
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
diet induced thermogenesis
ion transport
calcium ion transport
cellular calcium ion homeostasis
cell volume homeostasis
response to osmotic stress
hypotonic response
actin filament organization
cell-cell junction assembly
positive regulation of cytosolic calcium ion concentration
osmosensory signaling pathway
response to mechanical stimulus
positive regulation of gene expression
positive regulation of macrophage chemotaxis
negative regulation of neuron projection development
actin cytoskeleton organization
vasopressin secretion
positive regulation of microtubule depolymerization
positive regulation of interleukin-6 production
response to insulin
ion transmembrane transport
cellular response to heat
hyperosmotic salinity response
glucose homeostasis
positive regulation of vascular permeability
cortical microtubule organization
positive regulation of striated muscle contraction
positive regulation of JNK cascade
microtubule polymerization
regulation of response to osmotic stress
positive regulation of inflammatory response
multicellular organismal water homeostasis
transmembrane transport
cartilage development involved in endochondral bone morphogenesis
positive regulation of ERK1 and ERK2 cascade
calcium ion import
calcium ion transmembrane transport
cellular response to osmotic stress
cellular hypotonic response
cellular hypotonic salinity response
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
positive regulation of chemokine (C-C motif) ligand 5 production
energy homeostasis
blood vessel endothelial cell delamination
calcium ion import across plasma membrane
calcium ion import into cytosol
negative regulation of brown fat cell differentiation
regulation of aerobic respiration
positive regulation of chemokine (C-X-C motif) ligand 1 production
actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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