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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
SMU1 (suppressor of Mec8 and Unc-52 homolog), also known as BWD (brain-enriched WD), is a member of the WD-repeat SMU1 family and contains one CTLH domain, one LisH domain and six WD-repeats. SMU1 is a homolog of the C. elegans protein Smu1, a ubiquitously expressed nuclear protein that is believed to play a role in alternative splicing events of Unc-52. In mammals, SMU1 is a component of the spliceosome and appears to exhibit a conserved function, affecting the splicing of the mammalian Unc-52 homolog, namely Perlecan. Mutations in the gene encoding SMU1 may affect the function of the spliceosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brain-enriched WD repeat-containing protein; brain-enriched WD-repeat protein; functional spliceosome-associated protein 57; homolog of C. elegans smu-1; smu-1 suppressor of mec-8 and unc-52 homolog; Smu-1 suppressor of mec-8 and unc-52 protein homolog; suppressor of Mec and Unc defects 1 homolog; WD40 repeat-containing protein SMU1
Gene Aliases: 2600001O03Rik; 2610203K23Rik; AB044414; AI845086; AW556129; BWD; fSAP57; SMU-1; SMU1
UniProt ID: (Human) Q2TAY7, (Mouse) Q3UKJ7, (Rat) Q99M63
Entrez Gene ID: (Human) 55234, (Mouse) 74255, (Rat) 117541
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