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Invitrogen
PRMT5 Polyclonal Antibody
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Product Details
PA5-19172
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (RACREKDRDPEAQ) corresponding to the internal amino acids of PRMT5 (aa 485-498).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 72 kDa ICln-binding protein; EC 2.1.1.125; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; homolog of fission yeast Skb1; Jak-binding protein 1; JBP1; homodimer; PRMT5; Protein arginine N-methyltransferase 5; Shk1 kinase-binding protein 1 homolog; SKB1; SKB1 homolog; unnamed protein product
Gene Aliases: HRMT1L5; HSL7; IBP72; JBP1; PRMT5; SKB1; SKB1Hs
UniProt ID: (Human) O14744
Entrez Gene ID: (Human) 10419
p53 binding
transcription corepressor activity
protein binding
methyltransferase activity
methyl-CpG binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
transferase activity
protein-arginine omega-N symmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
ribonucleoprotein complex binding
histone methyltransferase activity (H4-R3 specific)
macromolecular complex binding
protein heterodimerization activity
E-box binding
histone H3 methyltransferase activity
spliceosomal snRNP assembly
chromatin organization
chromatin remodeling
DNA-templated transcription, termination
regulation of transcription, DNA-templated
regulation of mitotic nuclear division
regulation of gene expression
peptidyl-arginine methylation
methylation
circadian regulation of gene expression
peptidyl-arginine N-methylation
endothelial cell activation
hypermethylation of CpG island
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of mRNA splicing, via spliceosome
rhythmic process
positive regulation of oligodendrocyte differentiation
regulation of ERK1 and ERK2 cascade
Golgi ribbon formation
liver regeneration
regulation of signal transduction by p53 class mediator
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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