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Product Details
18078-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
Assay-dependent | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:1,000 | - |
Immunocytochemistry (ICC/IF) |
Assay-dependent | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse |
Published species |
Bovine, Cat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PDE10A Fusion Protein Ag12771 (434-779 aa encoded by BC104860) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.19 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: KLSYHSICT SEEWQGLMQF TLPVRLCKEI ELFHFDIGPF ENMWPGIFVY MVHRSCGTSC FELEKLCRFI MSVKKNYRRV PYHNWKHAVT VAHCMYAILQ NNHTLFTDLE RKGLLIACLC HDLDHRGFSN SYLQKFDHPL AALYSTSTME QHHFSQTVSI LQLEGHNIFS TLSSSEYEQV LEIIRKAIIA TDLALYFGNR KQLEEMYQTG SLNLNNQSHR DRVIGLMMTA CDLCSVTKLW PVTKLTANDI YAEFWAEGDE MKKLGIQPIP MMDRDKKDEV PQGQLGFYNA VAIPCYTTLT QILPPTEPLL KACRDNLSQW EKVIRGEETA TWISSPSVAQ KAAASED (434-779 aa encoded by BC104860 )
Target Information
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase; FLJ11894; FLJ25677; PDE10A2 brain-specific isoform
Gene Aliases: Pde10a
UniProt ID: (Mouse) Q8CA95
Entrez Gene ID: (Mouse) 23984
Molecular Function:
phosphodiesterase
nucleotide binding
catalytic activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
drug binding
hydrolase activity
cAMP binding
cGMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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