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Product Details
PD12-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 420-470 on human PDE12A protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2',5'-phosphodiesterase 12; 2'-PDE; 2'-phosphodiesterase; 2-PDE; Mitochondrial deadenylase
Gene Aliases: 2'-PDE; 2-PDE; E430028B21Rik; LRRGT00074; PDE12; RGD1310975
UniProt ID: (Human) Q6L8Q7, (Mouse) Q3TIU4
Entrez Gene ID: (Human) 201626, (Mouse) 211948, (Rat) 306231
poly(A)-specific ribonuclease activity
metal ion binding
molecular_function
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
photoreceptor cyclic-nucleotide phosphodiesterase activity
nuclease activity
exonuclease activity
hydrolase activity
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
inositol phosphosphingolipid phospholipase activity
inositol phosphorylceramide phospholipase activity
mannosyl-inositol phosphorylceramide phospholipase activity
mannosyl-diinositol phosphorylceramide phospholipase activity
mRNA polyadenylation factor
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