PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
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Protein Aliases: 2',5'-phosphodiesterase 12; 2'-PDE; 2'-phosphodiesterase; 2-PDE; Mitochondrial deadenylase
Gene Aliases: 2'-PDE; 2-PDE; E430028B21Rik; LRRGT00074; PDE12; RGD1310975
Molecular Function: mRNA polyadenylation factor