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Fabgennix
PDE4B2 Polyclonal Antibody
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Product Details
PD4B2-251AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide selective only to PDE4B2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic AMP phosphodiesterase; 3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase 4B; DPDE4; dunce-like phosphodiesterase E4; PDE32; PDE4B; PDE4B5; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); unnamed protein product
Gene Aliases: DPDE4; dunce; PDE4/IVb; PDE4B; Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDEIVB; R74983
UniProt ID: (Human) Q07343, (Rat) P14646
Entrez Gene ID: (Human) 5142, (Rat) 24626, (Mouse) 18578
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
cAMP binding
gamma-tubulin binding
ion channel binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
phosphodiesterase
neutrophil homeostasis
cAMP catabolic process
signal transduction
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to xenobiotic stimulus
cellular response to epinephrine stimulus
negative regulation of adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of cAMP/PKA signal transduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
smooth muscle contraction
metabolic process
cellular response to drug
regulation of high voltage-gated calcium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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