Bioss

PGC1 alpha + beta Polyclonal Antibody

View all (3) PGC1 alpha/beta antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

BS-1832R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human PPARGC1A.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ERR ligand 1; L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1alpha; Pgc-1alphaa; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARgamma coactivator 1 beta; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC-1-beta

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Gene Aliases: 4631412G21Rik; A830037N07Rik; ENSMUSG00000079510; ERRL1; Gm11133; LEM6; PERC; PGC-1; PGC-1(alpha); PGC-1(beta); PGC-1alpha; PGC-1v; PGC1; PGC1A; PGC1B; PGC1beta; Pgco1; PPARGC1; PPARGC1A; PPARGC1B

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UniProt ID: (Human) Q9UBK2, (Human) Q86YN6, (Mouse) O70343, (Rat) Q9QYK2, (Rat) Q811R2, (Mouse) Q8VHJ7

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Entrez Gene ID: (Human) 10891, (Human) 133522, (Mouse) 19017, (Rat) 83516, (Rat) 291567, (Mouse) 170826

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Function(s)
nucleotide binding RNA polymerase II transcription cofactor activity DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding ligand-dependent nuclear receptor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity chromatin DNA binding ubiquitin protein ligase binding peroxisome proliferator activated receptor binding alpha-tubulin binding sequence-specific DNA binding androgen receptor binding promoter-specific chromatin binding receptor activator activity AF-2 domain binding nucleic acid binding chromatin binding molecular_function transcription cofactor
Process(es)
response to reactive oxygen species mitophagy temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to dietary excess response to ischemia galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing protein complex assembly mitochondrion organization positive regulation of transcription from RNA polymerase II promoter by pheromones aging digestion circadian rhythm androgen metabolic process RNA splicing response to cold positive regulation of mitochondrion organization skeletal muscle atrophy response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration fatty acid oxidation cerebellum development respiratory electron transport chain androgen receptor signaling pathway forebrain development circadian regulation of gene expression cellular response to oxidative stress positive regulation of histone acetylation cellular response to potassium ion response to statin response to drug response to starvation regulation of circadian rhythm response to leucine negative regulation of neuron apoptotic process cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity flavone metabolic process adipose tissue development cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission cellular response to thyroid hormone stimulus negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of energy homeostasis positive regulation of ATP biosynthetic process ossification transcription from mitochondrial promoter actin filament organization positive regulation of alkaline phosphatase activity intracellular estrogen receptor signaling pathway cellular response to reactive oxygen species positive regulation of phosphorylation positive regulation of osteoclast differentiation positive regulation of bone resorption negative regulation of transcription, DNA-templated response to glucocorticoid response to cAMP bone trabecula formation positive regulation of receptor activity transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of cellular metabolic process rhythmic process response to hypoxia response to organic cyclic compound response to activity response to nutrient levels cellular response to fatty acid
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