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Invitrogen
PIK3CB Polyclonal Antibody
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FIGURE: 1 / 2
PIK3CB Antibody (PA5-80900) in ICC/IF
Immunofluorescence staining of PIK3CB in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with PIK3CB Polyclonal Antibody (Product # PA5-80900, 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-80900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the center region of the Human PIK3CB
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has specificity for Human PIK3CB.
Target Information
PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 110 kda catalytic subunit; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB; unnamed protein product
Gene Aliases: P110BETA; PI3K; PI3KBETA; PIK3C1
UniProt ID: (Human) P42338
Entrez Gene ID: (Human) 5291
regulation of cell-matrix adhesion
leukocyte mediated immunity
response to ischemia
sphingosine-1-phosphate signaling pathway
chemotaxis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of autophagy
positive regulation of endothelial cell migration
positive regulation of gene expression
cell migration
regulation of cell adhesion
platelet activation
positive regulation of neutrophil apoptotic process
positive regulation of Rac protein signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
natural killer cell mediated cytotoxicity
negative regulation of MAPK cascade
protein kinase B signaling
innate immune response
positive regulation of nitric oxide biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of protein kinase B signaling
platelet aggregation
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
regulation of clathrin-mediated endocytosis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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