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Invitrogen
PLXND1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 8
PLXND1 Antibody (PA5-47012) in IHC (P)
Immunohistochemical analysis of PLXND1 in immersion fixed paraffin-embedded sections of human melanoma. Samples were incubated in PLXND1 polyclonal antibody (Product # PA5-47012) using a dilution of 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Goat HRP-DA... View More
Product Details
PA5-47012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Plexin D1 Leu47-Ala1271
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576367
Product Specific Information
In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse (rm) Plexin A1, rmPlexin A3, and recombinant human Plexin B1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC75353; Plexin-D1
Gene Aliases: KIAA0620; PLEXD1; PLXND1
UniProt ID: (Human) Q9Y4D7
Entrez Gene ID: (Human) 23129
angiogenesis
patterning of blood vessels
outflow tract morphogenesis
cardiac septum development
synapse assembly
branchiomotor neuron axon guidance
regulation of cell migration
positive regulation of protein binding
aorta development
endothelial cell migration
regulation of angiogenesis
regulation of axon extension involved in axon guidance
dichotomous subdivision of terminal units involved in salivary gland branching
coronary vasculature development
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in axon guidance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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