PA5-28853 targets PNK in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28853 immunogen is recombinant fragment corresponding to a region within amino acids 78 and 521 of Human PNK.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5 and apos; phosphorylation and 3 and apos; dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
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Protein Aliases: 2'(3')-polynucleotidase; Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; EIEE10; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); MCSZ; PNK; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; Polynucleotide kinase-3'-phosphatase
Gene Aliases: AOA4; EIEE10; MCSZ; PNK; PNKP
UniProt ID: (Human) Q96T60
Entrez Gene ID: (Human) 11284