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Proteintech
PON3 Polyclonal Antibody
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Product Details
31793-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PON3 fusion protein Ag36602
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Amount
82.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: AFRERVNASR EVEPVEPENC HLIEELESGS EDIDILPSGL AFISSGLKYP GMPNFAPDEP GKIFLMDLNE QNPRAQALEI SGGFDKELFN PHGISIFIDK DNTVYLYVVN HPHMKSTVEI FKFEEQQRSL VYLKTIKHEL LKSVN
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase that is tightly associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to development of atherosclerosis such as in type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, indicating the involvement of PON1 in atherosclerosis development. PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs from it in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the 3 conserved cysteine residues identified in PON1, suggesting their importance of in vivo activities. PON1-based catalytic scavengers can be a way to safe and effective organophosphate intoxication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arylesterase 3; lactonase; paraoxanase-3; Serum paraoxonase/lactonase 3; unnamed protein product
Gene Aliases: 2810004E20; AI786302; PON3
UniProt ID: (Human) Q15166, (Rat) Q68FP2, (Mouse) Q62087
Entrez Gene ID: (Human) 5446, (Rat) 312086, (Mouse) 269823
phenylacetate catabolic process
dephosphorylation
aromatic compound catabolic process
coumarin catabolic process
carboxylic acid catabolic process
renal sodium ion transport
response to toxic substance
negative regulation of superoxide anion generation
establishment of localization in cell
lactone catabolic process
regulation of cellular response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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