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Invitrogen
POU3F3 Polyclonal Antibody
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FIGURE: 1 / 2
POU3F3 Antibody (PA5-70366) in IHC (P)
Immunohistochemical analysis of POU3F3 in paraffin-embedded human adult heart tissue. Sample was probed with a POU3F3 polyclonal antibody (Product # PA5-70366) at a dilution of 1:600. Detection was performed with a donkey anti-Rabbit Cy2/3 secondary antibody at a dilution of 1:200. Images were taken at 20x magnification with an exposure time of 0.5-2.0 seconds.
Product Details
PA5-70366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the C-terminal region of rat POU3F3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Dog: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Target Information
POU3F3 is a member of the class III POU family of transcription factors that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8-Oct; Brain-1; Brain-specific homeobox/POU domain protein 1; brn-1 protein; class III POU protein POU-domain; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF-8; POU domain, class 3, transcription factor 3
Gene Aliases: brain-1; Brn-1; BRN1; oct-8; OTF8; POU3F3; RHS1; Rhs2; SNIBFIS
UniProt ID: (Human) P20264, (Rat) Q63262
Entrez Gene ID: (Human) 5455, (Rat) 192109
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
sequence-specific DNA binding
HMG box domain binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
kidney development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
brain development
positive regulation of cell proliferation
positive regulation of gene expression
cerebral cortex radially oriented cell migration
forebrain ventricular zone progenitor cell division
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
chemical homeostasis
urea transmembrane transport
metanephric ascending thin limb development
metanephric macula densa development
metanephric thick ascending limb development
metanephric loop of Henle development
metanephric DCT cell differentiation
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription from RNA polymerase II promoter
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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