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Bioss
PPT1 Polyclonal Antibody
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Product Details
BS-6619R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PPT1, amino acids 188-290.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3.1.2.22; ceroid-palmitoyl-palmitoyl-protein thioesterase 1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein thioesterase 1; PPT-1; PPT1; unnamed protein product
Gene Aliases: 9530043G02Rik; AA960502; C77813; CLN1; D4Ertd184e; INCL; PPT; PPT1
UniProt ID: (Human) P50897, (Rat) P45479, (Mouse) O88531
Entrez Gene ID: (Human) 5538, (Rat) 29411, (Mouse) 19063
protein depalmitoylation
endocytosis
receptor-mediated endocytosis
pinocytosis
lysosome organization
lysosomal lumen acidification
neurotransmitter secretion
nervous system development
brain development
visual perception
grooming behavior
associative learning
adult locomotory behavior
macromolecule catabolic process
protein transport
lipid catabolic process
sphingolipid catabolic process
protein catabolic process
negative regulation of cell growth
membrane raft organization
toll-like receptor 9 signaling pathway
negative regulation of toll-like receptor 9 signaling pathway
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
fatty-acyl-CoA biosynthetic process
positive regulation of receptor-mediated endocytosis
positive regulation of pinocytosis
neuron development
regulation of synapse structure or activity
chemical synaptic transmission
regulation of phospholipase A2 activity
cellular protein catabolic process
cellular macromolecule catabolic process
regulation of synaptic plasticity
cofactor transport
cofactor metabolic process
macromolecule depalmitoylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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