Immunogen sequence: AREALATLKP QAGLIVPQAV PSSQPSVVGA GEPMDLGELV GMTPEIIQKL QDKATVLTTE RKKRGKTVPE ELVKPEELSK YRQVASHVGL HSASIPGILA LDLCPSDTNK ILTGGADKNV VVFDKSSEQI LATLKGHTKK VTSVVFHPSQ DLVFSASPDA TIRIWSVPNA SCVQVVRAHE SAVTGLSLHA TGDYLLSSSD DQYWAFSDIQ TGRVLTKVTD ETSGCSLTCA QFHPDGLIFG TGTMDSQIKI WDLKERTNVA NFPGHSGPIT SIAFSENGYY LATAADDSSV; Positive Samples: HepG2, Jurkat, HeLa, Mouse heart, Rat brain; Cellular Location: Cytoplasm, Lipid droplet, Nucleus, cytoskeleton, nucleoplasm, spindle
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
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Protein Aliases: hPso4; Neuronal differentiation-related gene protein; Nuclear matrix protein 200; nuclear matrix protein NMP200 related to splicing factor PRP19; nuclear matrix protein SNEV; Pre-mRNA-processing factor 19; prp19 beta; PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog; psoralen 4; RING-type E3 ubiquitin transferase PRP19; Senescence evasion factor
Gene Aliases: AA617263; AL024362; D19Wsu55e; hPSO4; NMP200; PRP19; PRPF19; PSO4; SNEV; UBOX4