This antibody is predicted to react with bovine, human, mouse, non-human primate and zebrafish based on 100% sequence homology.
This antibody is specific for ~95 kDa PSD-95 protein.
PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other protein in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Discs large homolog 4; Disks large homolog 4; Human post-synaptic density protein 95; Postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; SAP90; Synapse associated protein 90; Synapse-associated protein 90; synapse-associated protein SAP90
Gene Aliases: Dlg4; Dlgh4; PSD-95; PSD95; SAP90; SAP90A