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Invitrogen
PSMD2 Polyclonal Antibody
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FIGURE: 1 / 5
PSMD2 Antibody (PA5-144641) in ICC/IF
Immunocytochemistry analysis of PSMD2 in SiHa cells. Cells were fixed in 4% paraformaldehyde for 10 minutes at 37 &(8)451;, permeabilized with 0.05% Triton X-100 in PBS for 20 minutes, and then blocked with 2% negative goat serum for 30 minutes at room temperature. Cells were incubated with PSMD2 polyclonal antibody (Product # PA5-144641) with a dilution of 1:200 in 2% negative goat serum overnight at 4 &(8)451;. Followed by secondary antibody Goat Anti-Rabbit IgG H&L (iFluor™ 488) at a dilution of 1:1,000. PBS instead of the primary antib... View More
Product Details
PA5-144641
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human PSMD2 aa 1-200/908.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive control: 293T cell lysate, Jurkat cell lysate, Hela cell lysate, NIH/3T3 cell lysate, mouse heart tissue lysate, rat testis tissue lysate, rat heart tissue lysate, SiHa, rat large intestine tissue, human lung carcinoma tissue, human striated muscle tissue, mouse heart tissue.
Predicted band size: 100 kDa
Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, proteasome storage granule.
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; F23F1.8; MGC14274; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S subunit, non-ATPase 2; Protein 55.11; testis expressed gene 190; TNFR-associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; unnamed protein product
Gene Aliases: 9430095H01Rik; AA407121; P97; PSMD2; RPN1; S2; TEG-190; Tex190; TRAP2
UniProt ID: (Human) Q13200, (Rat) Q4FZT9, (Mouse) Q8VDM4
Entrez Gene ID: (Human) 5708, (Rat) 287984, (Mouse) 21762
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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