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Proteintech
PTP1B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
11334-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTP1B Fusion Protein Ag1878 (1-435 aa encoded by BC015660)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEMEKEFEQ IDKSGSWAAI YQDIRHEASD FPCRVAKLPK NKNRNRYRDV SPFDHSRIKL HQEDNDYINA SLIKMEEAQR SYILTQGPLP NTCGHFWEMV WEQKSRGVVM LNRVMEKGSL KCAQYWPQKE EKEMIFEDTN LKLTLISEDI KSYYTVRQLE LENLTTQETR EILHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLSPEHG PVVVHCSAGI GRSGTFCLAD TCLLLMDKRK DPSSVDIKKV LLEMRKFRMG LIQTADQLRF SYLAVIEGAK FIMGDSSVQD QWKELSHEDL EPPPEHIPPP PRPPKRILEP HNGKCREFFP NHQWVKEETQ EDKDCPIKEE KGSPLNAAPY GIESMSQDTE VRSRVVGGSL RGAQAASPAK GEPSLPEKDE DHALSYWKPF LVNMCVATVL TAGAYLCYRF LFNSNT (1-435 aa encoded by B C015660)
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTPase; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; unnamed protein product
Gene Aliases: Ptp; PTP-1B; PTP-HA2; PTP1B
UniProt ID: (Human) P18031, (Rat) P20417, (Mouse) P35821
Entrez Gene ID: (Human) 5770, (Rat) 24697, (Mouse) 19246
RNA binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
zinc ion binding
phosphatase activity
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
cadherin binding
ephrin receptor binding
protein phosphatase 2A binding
receptor binding
negative regulation of protein phosphorylation
positive regulation of systemic arterial blood pressure
protein dephosphorylation
negative regulation of cell proliferation
insulin receptor signaling pathway
regulation of signal transduction
positive regulation of heart rate
positive regulation of cardiac muscle cell apoptotic process
negative regulation of cell-substrate adhesion
negative regulation of neuron projection development
dephosphorylation
actin cytoskeleton organization
regulation of endocytosis
regulation of proteolysis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
response to nutrient levels
cellular response to insulin stimulus
regulation of intracellular protein transport
response to endoplasmic reticulum stress
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
cellular response to platelet-derived growth factor stimulus
IRE1-mediated unfolded protein response
insulin receptor recycling
negative regulation of MAP kinase activity
cellular response to fibroblast growth factor stimulus
positive regulation of JNK cascade
regulation of insulin receptor signaling pathway
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of protein kinase B signaling
negative regulation of ERK1 and ERK2 cascade
cellular response to hypoxia
cellular response to nitric oxide
regulation of postsynapse assembly
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
cellular response to angiotensin
negative regulation of vascular associated smooth muscle cell migration
cellular response to nerve growth factor stimulus
response to angiotensin
positive regulation of endothelial cell apoptotic process
positive regulation of receptor catabolic process
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of signal transduction
cellular response to unfolded protein
negative regulation of insulin receptor signaling pathway
regulation of type I interferon-mediated signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
vascular endothelial cell response to oscillatory fluid shear stress
positive regulation of IRE1-mediated unfolded protein response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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