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Proteintech

PTP1B Polyclonal Antibody

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View all (34) PTP1B antibodies

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PTP1B Polyclonal Antibody

Product Details

11334-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
View 25 publications 25 publications

Immunohistochemistry (IHC)

-
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg
View 4 publications 4 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PTP1B Fusion Protein Ag1878 (1-435 aa encoded by BC015660)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEMEKEFEQ IDKSGSWAAI YQDIRHEASD FPCRVAKLPK NKNRNRYRDV SPFDHSRIKL HQEDNDYINA SLIKMEEAQR SYILTQGPLP NTCGHFWEMV WEQKSRGVVM LNRVMEKGSL KCAQYWPQKE EKEMIFEDTN LKLTLISEDI KSYYTVRQLE LENLTTQETR EILHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLSPEHG PVVVHCSAGI GRSGTFCLAD TCLLLMDKRK DPSSVDIKKV LLEMRKFRMG LIQTADQLRF SYLAVIEGAK FIMGDSSVQD QWKELSHEDL EPPPEHIPPP PRPPKRILEP HNGKCREFFP NHQWVKEETQ EDKDCPIKEE KGSPLNAAPY GIESMSQDTE VRSRVVGGSL RGAQAASPAK GEPSLPEKDE DHALSYWKPF LVNMCVATVL TAGAYLCYRF LFNSNT (1-435 aa encoded by B C015660)

Target Information

PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1; unnamed protein product

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Gene Aliases: Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1

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UniProt ID: (Human) P18031, (Rat) P20417, (Mouse) P35821

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Entrez Gene ID: (Human) 5770, (Rat) 24697, (Mouse) 19246

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Function(s)
RNA binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity enzyme binding protein kinase binding receptor tyrosine kinase binding cadherin binding ephrin receptor binding protein phosphatase 2A binding poly(A) RNA binding protein phosphatase
Process(es)
positive regulation of systemic arterial blood pressure protein dephosphorylation negative regulation of cell proliferation insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction positive regulation of heart rate positive regulation of cardiac muscle cell apoptotic process negative regulation of cell-substrate adhesion negative regulation of neuron projection development actin cytoskeleton organization regulation of endocytosis regulation of proteolysis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response response to nutrient levels cellular response to insulin stimulus regulation of intracellular protein transport cellular response to unfolded protein response to endoplasmic reticulum stress peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus IRE1-mediated unfolded protein response insulin receptor recycling negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus positive regulation of JNK cascade regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to hypoxia cellular response to nitric oxide vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynapse assembly regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration cellular response to nerve growth factor stimulus response to angiotensin positive regulation of endothelial cell apoptotic process positive regulation of receptor catabolic process actin cytoskeleton reorganization peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity activation of JUN kinase activity dephosphorylation positive regulation of protein tyrosine kinase activity
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