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Invitrogen

Phospho-RAC1 (Ser71) Polyclonal Antibody

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Phospho-RAC1 (Ser71) Polyclonal Antibody

Product Details

PA5-110153

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S71 of human RAC1 (NP_008839.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.66 mg/mL

Amount

66 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2855564

Product Specific Information

Immunogen sequence: RPLSYP

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell migration-inducing gene 5 protein; MGC111543; p21-Rac1; Rac1ins; ras-like protein; ras-like protein TC25; ras-related C3 botulinum toxin substrate; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1; small GTP binding protein; Rac1; Rho-related protein; unnamed protein product

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Gene Aliases: MIG5; MRD48; p21-Rac1; Rac-1; TC-25

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UniProt ID: (Human) P63000, (Rat) Q6RUV5

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Entrez Gene ID: (Human) 5879, (Rat) 363875

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding macromolecular complex binding Rho GDP-dissociation inhibitor binding small GTPase binding histone deacetylase binding ATPase binding
Process(es)
neuron migration positive regulation of protein phosphorylation sphingosine-1-phosphate signaling pathway phagocytosis, engulfment inflammatory response actin filament organization cell adhesion cell-matrix adhesion establishment or maintenance of cell polarity enzyme linked receptor protein signaling pathway small GTPase mediated signal transduction motor neuron axon guidance regulation of cell shape response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process regulation of lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of endothelial cell migration regulation of fibroblast migration negative regulation of fibroblast migration regulation of cell-substrate adhesion cell migration Rac protein signal transduction cell projection assembly lamellipodium assembly actin cytoskeleton organization actin filament polymerization regulation of cell migration cortical cytoskeleton organization forebrain development ruffle organization response to lipopolysaccharide negative regulation of interleukin-23 production regulation of actin cytoskeleton organization substrate adhesion-dependent cell spreading positive regulation of Rho protein signal transduction intracellular signal transduction non-canonical Wnt signaling pathway positive regulation of insulin secretion involved in cellular response to glucose stimulus superoxide anion generation engulfment of apoptotic cell regulation of nitric oxide biosynthetic process respiratory burst regulation of JAK-STAT cascade hepatocyte growth factor receptor signaling pathway negative regulation of receptor-mediated endocytosis neuron projection morphogenesis cell motility regulation of stress fiber assembly positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cell chemotaxis regulation of cell adhesion involved in heart morphogenesis semaphorin-plexin signaling pathway positive regulation of neutrophil chemotaxis ruffle assembly regulation of postsynapse assembly positive regulation of substrate adhesion-dependent cell spreading positive regulation of ruffle assembly regulation of synaptic vesicle endocytosis regulation of neutrophil migration positive regulation of bicellular tight junction assembly midbrain dopaminergic neuron differentiation positive regulation of ovarian follicle development auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis endocytosis chemotaxis hyperosmotic response cytoskeleton organization G-protein coupled receptor signaling pathway axon guidance regulation of neuron maturation dendrite development cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development regulation of cell morphogenesis positive regulation of actin filament polymerization angiotensin-activated signaling pathway erythrocyte enucleation cell-cell junction organization bone resorption positive regulation of DNA replication regulation of neuronal synaptic plasticity anatomical structure arrangement dendrite morphogenesis multicellular organismal homeostasis homeostasis of number of cells within a tissue positive regulation of filopodium assembly positive regulation of protein kinase B signaling synaptic transmission, GABAergic positive regulation of dendritic spine development regulation of ERK5 cascade cellular response to mechanical stimulus dopaminergic neuron differentiation protein localization to plasma membrane cochlea morphogenesis postsynaptic actin cytoskeleton organization
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