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Invitrogen
RET Polyclonal Antibody
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FIGURE: 1 / 1
RET Antibody (PA5-85119) in WB
RET Polyclonal Antibody detects RET protein by western blot analysis. A. 30 µg U87-MG whole cell lysate/extract. B. 30 µg SK-N-SH whole cell lysate/extract. C. 30 µg IMR32 whole cell lysate/extract. D. 30 µg SK-N-AS whole cell lysate/extract.5 % SDS-PAGE. RET Polyclonal Antibody (Product # PA5-85119) dilution: 1:1,000.
Product Details
PA5-85119
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of human RET. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (94%), Rat (93%), Zebrafish (80%), Dog (92%).
Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. RET transduce signals for cell growth and differentiation. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 12; Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); cadherin-related family member 16; EC 2.7.10.1; ELKS; Hydroxyaryl protein kinase; kinase Ret; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; OTTHUMP00000216967; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; ret; RET ELE1; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; unnamed protein product
Gene Aliases: CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1
UniProt ID: (Human) P07949
Entrez Gene ID: (Human) 5979
MAPK cascade
ureteric bud development
neural crest cell migration
embryonic epithelial tube formation
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
neuron cell-cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
axon guidance
posterior midgut development
positive regulation of gene expression
positive regulation of neuron projection development
regulation of cell adhesion
neuron differentiation
positive regulation of cell migration
membrane protein proteolysis
positive regulation of cell adhesion mediated by integrin
ureter maturation
glial cell-derived neurotrophic factor receptor signaling pathway
neuron maturation
positive regulation of MAPK cascade
positive regulation of cell size
positive regulation of transcription, DNA-templated
response to pain
enteric nervous system development
regulation of axonogenesis
positive regulation of protein kinase B signaling
Peyer's patch morphogenesis
cellular response to retinoic acid
positive regulation of metanephric glomerulus development
lymphocyte migration into lymphoid organs
GDF15-GFRAL signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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