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RIPK2 Polyclonal Antibody

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RIPK2 Polyclonal Antibody

Product Details

RIPK2-201AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Bovine, Human, Non-human primate, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 410-460 on human RIPK2 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

RIPK2 is a serine/threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CARD domain protein; phosphorylated protein; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARDIAK; RIP-like kinase; EC 2.7.11.1; growth-in; growth-inhibiting gene 30; kinase RIPK2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; Receptor-interacting serine/threonine-protein kinase 2; RIP 2; RIP-2; RIP-like; RIP-like-interacting CLARP kinase; RIP2; serine/threonine kinase homolog; contains CARD motif; Tyrosine-protein kinase RIPK2; unnamed protein product; WUGSC:H_RG437L15.1

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Gene Aliases: CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2; UNQ277/PRO314/PRO34092

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UniProt ID: (Bovine) Q3SZJ2, (Human) O43353

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Entrez Gene ID: (Bovine) 534407, (Pig) 100518835, (Human) 8767

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Function(s)
non-membrane spanning protein tyrosine kinase activity receptor binding ATP binding LIM domain binding protein homodimerization activity CARD domain binding caspase binding nucleotide binding protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity protein tyrosine kinase activity protein binding kinase activity transferase activity signaling adaptor activity identical protein binding protein serine kinase activity non-receptor serine/threonine protein kinase
Process(es)
positive regulation of cytokine-mediated signaling pathway adaptive immune response apoptotic process I-kappaB kinase/NF-kappaB signaling activation of JNKK activity positive regulation of peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of protein binding positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of immature T cell proliferation positive regulation of peptidyl-serine phosphorylation toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway T cell proliferation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response positive regulation of T-helper 1 cell differentiation positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway response to interleukin-1 response to interleukin-12 response to interleukin-18 cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to muramyl dipeptide activation of cysteine-type endopeptidase activity positive regulation of xenophagy positive regulation of cytokine production immune system process positive regulation of T-helper 1 type immune response inflammatory response signal transduction JNK cascade cytokine-mediated signaling pathway positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of stress-activated MAPK cascade immature T cell proliferation in thymus positive regulation of immature T cell proliferation in thymus CD4-positive, alpha-beta T cell proliferation p38MAPK cascade defense response to bacterium regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade protein homooligomerization stress-activated MAPK cascade positive regulation of macrophage cytokine production ERK1 and ERK2 cascade cellular response to lipopolysaccharide regulation of primary metabolic process protein linear polyubiquitination xenophagy cell surface toll-like receptor signaling pathway positive regulation of protein K63-linked ubiquitination positive regulation of CD4-positive, alpha-beta T cell proliferation
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